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Updated: Jun 22, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Total therapy-based treatment for multiple myeloma--a single center experience
Hila Magen-Nativ1, Ron Ram, Moshe Yeshurun
1Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Petah-Tiqva, Israel.
Annals of Hematology
|June 9, 2009
Summary
This study shows that the intensified Arkansas protocol is an effective and safe multiple myeloma treatment. It achieved high remission rates and good survival in Israeli patients outside a clinical trial setting.
Area of Science:
- Hematology
- Oncology
- Clinical Research
Background:
- Novel biological agents are central to multiple myeloma treatment.
- The intensified Total Therapy 3 (Arkansas protocol) has shown promise.
- Real-world data on this protocol outside clinical trials is limited.
Purpose of the Study:
- To evaluate the efficacy and safety of the Arkansas protocol-based treatment for multiple myeloma.
- To assess outcomes in a tertiary medical center in Israel.
- To determine the effectiveness of this intensified approach in a non-trial setting.
Main Methods:
- Retrospective analysis of 23 multiple myeloma patients.
- Application of the Arkansas protocol with local modifications.
- Evaluation of remission rates, survival, and adverse events.
Main Results:
- 73% of patients achieved very good partial remission (VGPR) before autologous stem cell transplantation (ASCT).
- 86% achieved at least VGPR after tandem ASCT.
- Estimated 2-year overall survival was 70%; 4 treatment-related deaths occurred.
Conclusions:
- The Arkansas protocol demonstrates efficacy and acceptable safety in treating multiple myeloma.
- This intensified approach shows promise for real-world application.
- Further trials are needed to identify patient subgroups benefiting most from this protocol.
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