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Related Experiment Video

Updated: Jun 22, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
05:41

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

A highly reproducible continuous process for hydroxyapatite nanoparticles synthesis.

Paulo J Gomes1, Viviana M T M Silva, Paulo A Quadros

  • 1Fluidinova, Engenharia de Fluidos S.A., TecMaia-Rua Engenheiro Frederico Ulrich, 2650, 4470-605 Moreira da Maia, Portugal.

Journal of Nanoscience and Nanotechnology
|June 10, 2009
PubMed
Summary

This study introduces a continuous process for hydroxyapatite nanoparticle (NanoXIM) production using a network reactor. This method allows precise control over nanoparticle properties for diverse applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomaterials Engineering

Background:

  • Hydroxyapatite nanoparticles (NanoXIM) are versatile biomaterials with applications in medicine, food, and cosmetics.
  • Existing production methods may lack precise control over nanoparticle characteristics.
  • The demand for tailored hydroxyapatite nanoparticles necessitates advanced synthesis techniques.

Purpose of the Study:

  • To develop and present a continuous process for hydroxyapatite nanoparticle synthesis.
  • To demonstrate the control over nanoparticle properties (purity, crystallinity, morphology) through process parameters.
  • To explore the potential of network reactor technology for nanomaterial production.

Main Methods:

  • Continuous synthesis of hydroxyapatite nanoparticles in a network reactor (NETmix).

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Last Updated: Jun 22, 2026

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  • Controlled feeding of calcium, phosphorus, and alkaline solutions.
  • Precise management of reactant distribution, pH, supersaturation, Ca/P ratio, and temperature.
  • Post-reactor processing including aging, separation, drying, sintering, and milling.

    • Main Results:

    • Successful continuous production of hydroxyapatite nanoparticles.
    • Demonstrated ability to control micromixing for nanostructure formation.
    • Established influence of process parameters on crystal purity, crystallinity, and morphology.
    • Production of calcium phosphate nanoparticle suspension for further refinement.

    Conclusions:

    • The NETmix reactor offers a controlled environment for continuous hydroxyapatite nanoparticle synthesis.
    • Process parameter optimization is key to tailoring NanoXIM properties for specific applications.
    • This continuous process holds promise for scalable and precise biomaterial production.