Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 22, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Nanodiamond as promising material for bone tissue engineering.

Lubica Grausova1, Lucie Bacakova, Alexander Kromka

  • 1Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.

Journal of Nanoscience and Nanotechnology
|June 10, 2009
PubMed
Summary

Nanocrystalline diamond (NCD) films enhance human osteoblast-like cell adhesion, growth, and differentiation. These biocompatible diamond surfaces show promise for improving bone implant integration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Steam-sterilizable cationic nanodiamond-silver composites with enhanced antibacterial activity.

Nanoscale advances·2026
Same author

Balancing antibacterial effects and cytotoxicity through LIFT-fabricated AgNP microdomain arrays on PET.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Development of a 3D In Vitro Model of Dupuytren's Disease as a Platform for Drug Screening.

Cellular and molecular bioengineering·2026
Same author

Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical Applications.

Biopolymers·2026
Same author

Suspendable and Scalable Ultrasound-Actuated ZnO-Nanosheet-Based Piezoelectric Microdevices for Wireless Electrical Stimulation of Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Collagen-hyaluronic acid hydrogel with embedded chondrocytes as a platform for modeling early stages of endochondral ossification <i>in vitro</i>.

Cell transplantation·2026

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cell Biology

Background:

  • Bone tissue engineering requires biomaterials that promote osteoblast function.
  • Nanostructured surfaces offer unique properties for cell interactions.
  • Current bone implants face challenges with osseointegration.

Purpose of the Study:

  • To evaluate the effect of nanostructured nanocrystalline diamond (NCD) films on human osteoblast-like MG 63 cell behavior.
  • To compare cell adhesion, growth, and differentiation on NCD with varying surface roughness against polystyrene controls.
  • To explore the potential of NCD films for bone implant surface modification.

Main Methods:

  • Human osteoblast-like MG 63 cells were cultured on low roughness NCD and hierarchically micro- and nanostructured NCD films.

More Related Videos

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Related Experiment Videos

Last Updated: Jun 22, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

  • Cell adhesion, proliferation (cell counting), viability (LIVE/DEAD assay), metabolic activity (XTT assay), and differentiation (osteocalcin expression) were assessed.
  • Surface characterization included roughness measurements (rms) and contact angle measurements.

    • Main Results:

    • Significantly higher cell numbers and adhesion area were observed on both NCD surfaces compared to polystyrene.
    • Cell viability remained high (98-100%) on NCD films.
    • Metabolic activity was 2-3 times higher on NCD, and osteocalcin expression indicated enhanced osteogenic differentiation.

    Conclusions:

    • Nanocrystalline diamond films support osteoblast adhesion, proliferation, and differentiation.
    • Hierarchically structured NCD surfaces further enhance cell adhesion.
    • NCD films are promising for developing improved bone implant surfaces to promote osseointegration.