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Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical

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Summary
This summary is machine-generated.

This study introduces novel biocompatible composite films made from polycaprolactone (PCL), MXene, and gelatin for biomedical uses. Porcine gelatin-based films demonstrated superior cell growth, indicating promising potential for tissue engineering applications.

Keywords:
MXenebiocompatibilitygelatinmechanical propertiesnanoscale morphologypolycaprolactone

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Polymer Science

Background:

  • Developing biocompatible films with balanced mechanical properties and bioactivity is crucial for biomedical applications.
  • Existing platforms like scaffolds, films, and hydrogels face challenges in achieving this balance.
  • Polycaprolactone (PCL) and gelatin offer a promising matrix, while MXenes can enhance properties.

Purpose of the Study:

  • To develop biocompatible composite films using PCL, MXene, and different gelatin types (bovine, fish, porcine).
  • To investigate the influence of gelatin source on the films' chemical structure, morphology, physicochemical properties, cytotoxicity, and cell growth.
  • To assess the potential of these composite films for biomedical applications.

Main Methods:

  • Fabrication of composite films using PCL, MXene, and three types of gelatin.
  • Characterization of chemical structure, morphology (SEM/SE), and physicochemical properties (tensile strength, SAXS, WAXS).
  • In vitro cytotoxicity and cell growth studies using SAOS-2 cells.

Main Results:

  • All films exhibited high tensile strength (5–10 MPa).
  • MXene incorporation (0.5 wt%) significantly altered tensile properties in films with lower gelatin content (12-15 wt%).
  • SEM/SE revealed decreasing structure coarseness in the order PCL/MX/fish gelatin > PCL/MX/bovine gelatin > PCL/MX/porcine gelatin.
  • SAOS-2 cell confluence was highest on films with 14.5 wt% porcine gelatin.

Conclusions:

  • The developed PCL/MXene/gelatin composite films show tunable mechanical properties and good biocompatibility.
  • Porcine gelatin-based films demonstrate superior cell proliferation, suggesting their potential for enhanced tissue regeneration.
  • These findings highlight the promise of MXene-gelatin composites as advanced biomaterials.