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Target organ damage: how to detect it and how to treat it?

Bernard Waeber1, Alejandro de la Sierra, Luis M Ruilope

  • 1Division of Clinical Pathophysiology, Centre Hospitalier Universitaire de Lausanne et Université de Lausanne, Lausanne, Switzerland. Bernard.Waeber@chuv.ch

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|June 10, 2009
PubMed

Insights

Early detection of cardiac damage in hypertensive patients is crucial for risk profiling. Microalbuminuria testing is a cost-effective method for identifying cardiovascular and renal complications, guiding treatment with renin-angiotensin system blockers.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Early detection of cardiac organ damage is vital for cardiovascular risk assessment in hypertensive patients.
  • Microalbuminuria determination is a cost-effective method for identifying potential cardiovascular and renal complications.
  • Target organ damage in hypertension necessitates effective treatment strategies.

Purpose of the Study:

  • To highlight the importance of early detection of cardiac organ damage in hypertension.
  • To emphasize the role of microalbuminuria in identifying complications.
  • To discuss the therapeutic benefits of renin-angiotensin system blockers in managing target organ damage.

Main Methods:

  • Review of current clinical practices and research regarding hypertension management.
  • Analysis of the diagnostic value of microalbuminuria.
  • Evaluation of the efficacy of renin-angiotensin system blockers and combination therapies.

Main Results:

  • Microalbuminuria serves as a cost-effective marker for cardiovascular and renal complications in hypertension.
  • Renin-angiotensin system blockers effectively regress left ventricular hypertrophy, reduce albuminuria, and slow nephropathy progression.
  • Combination therapy with calcium antagonists may be beneficial for blood pressure control in high-risk patients.

Conclusions:

  • Early identification of cardiac organ damage through microalbuminuria is key in hypertensive patients.
  • Renin-angiotensin system blockers are essential for managing target organ damage, offering regression of hypertrophy and protection against renal decline.
  • Combined blockade of the renin-angiotensin system and calcium antagonists can be a judicious approach for blood pressure management in high-risk individuals.

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