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Multisite neuroimaging trials.

John Darrell Van Horn1, Arthur W Toga

  • 1Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-7334, USA. jvanhorn@loni.ucla.edu

Current Opinion in Neurology
|June 10, 2009
PubMed
Summary

Multicenter neuroimaging trials are increasingly vital for understanding brain disorders and improving clinical treatments. These collaborative efforts generate large datasets essential for research and patient care.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Clinical Research

Background:

  • Magnetic Resonance Imaging (MRI) is a key technology for assessing brain structure and function.
  • Increased availability of MRI and geographic distribution of patient populations have spurred multicenter neuroimaging trials.
  • These trials are crucial for studying progressive brain changes, treatment biomarkers, and disease effects on cognition.

Purpose of the Study:

  • To review trends in multicenter neuroimaging trials.
  • To evaluate their value for research.
  • To understand their implications for clinical treatment.

Main Methods:

  • Review of trends in multicenter neuroimaging trials.
  • Analysis of their role in research and clinical applications.

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Main Results:

  • A rise in multicenter neuroimaging trials and consortia focusing on diseases like Alzheimer's, pediatric brain cancer, and fetal alcohol syndrome.
  • These trials are essential for mapping the normal brain and understanding disease progression.
  • Large-scale efforts require coordinated data collection, protocol standardization, computational resources, and data sharing.

Conclusions:

  • Multicenter neuroimaging trials facilitate the creation of large, targeted datasets.
  • These datasets aid in modeling and predicting clinical outcomes for neurological diseases.
  • Findings can guide clinicians in treatment selection for neurological conditions.