Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sarcopenia Versus Systemic Inflammation as Predictors of New Vertebral Fractures After Vertebroplasty or Kyphoplasty: A Retrospective Cohort Study.

Journal of clinical medicine·2026

Same author

Comparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026

Same author

Impact of Tricuspid Regurgitation Severity and Right Ventricular Function on the Correlation and Agreement Between Transthoracic Echocardiography- and Right Heart Catheterization-Derived Systolic Pulmonary Artery Pressure.

Cureus·2026

Same author

Surfaced-based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning.

Epilepsia·2025

Same author

Developing an advanced risk stratification model for pediatric intracranial ependymoma based on the prospective trial E-HIT2000 and subsequent registries.

Neuro-oncology·2025

Same author

Polymer-water partition coefficients of butyl rubber and polydimethylsiloxane passive samplers for polycyclic aromatic hydrocarbons using the co-solvent method.

Environmental science and pollution research international·2025

Same journal

Pertussistoxin as well as Staphylococcal superantigen induce glycolysis as energy source during T cell activation in an adenoid organoid model.

Clinical science (London, England : 1979)·2026

Same journal

Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway.

Clinical science (London, England : 1979)·2026

Same journal

Edaravone Dexborneol regulates the endothelial PPARγ-PON1 axis to inhibit high-cholesterol-induced atherosclerosis.

Clinical science (London, England : 1979)·2026

Same journal

HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion.

Clinical science (London, England : 1979)·2026

Same journal

Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway.

Clinical science (London, England : 1979)·2026

Same journal

Human cytomegalovirus at the maternal-fetal interface: an overview of pathogenesis, defence, and interventions.

Clinical science (London, England : 1979)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain.

Atilla Yilmaz¹, Tanja Fuchs, Barbara Dietel

¹Clinic of Internal Medicine I, Department of Cardiology, University Hospital Jena, Jena, Germany. A.Yilmaz@web.de

Clinical Science (London, England : 1979)

|June 11, 2009

Summary

This summary is machine-generated.

Acute stroke significantly reduces circulating dendritic cell precursors (DCPs), which are recruited to the brain, potentially triggering immune responses. Numbers recover in the days following stroke.

More Related Videos

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Jun 22, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

Area of Science:

Neuroimmunology
Cerebrovascular Diseases
Inflammation

Background:

Dendritic cells (DCs) are key immune mediators, but their role in stroke remains under-investigated.
Understanding DC dynamics in stroke is crucial for developing targeted therapies.

Purpose of the Study:

To investigate circulating myeloid DC precursors (mDCPs), plasmacytoid DCPs (pDCPs), and total DCPs in various stroke types.
To correlate DCP levels with stroke severity, infarct size, and inflammatory markers.
To examine DC infiltration in the infarcted brain.

Main Methods:

Flow cytometry analysis of circulating DCPs in healthy controls and patients with stroke (ACI-S, TIA, AIS, AHS).
Evaluation of NIHSS and CT-determined infarct size.
Post-mortem immunohistochemical analysis of brain tissue for DCs, T-cells, and HLA-DR.

Main Results:

Acute ischemic stroke (AIS) and acute hemorrhagic stroke (AHS) showed significantly reduced circulating mDCPs, pDCPs, and tDCPs.
Circulating DCP levels inversely correlated with NIHSS scores and hsCRP levels.
Larger infarct sizes were associated with lower DCP counts, with recovery observed in early follow-up.

Conclusions:

Acute stroke causes a significant decrease in circulating dendritic cell precursors.
Circulating DCPs are likely recruited to the infarcted brain, contributing to cerebral immune responses.
These findings highlight the involvement of DCs in stroke-related inflammation.