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[The dynamics of trace elements in eye tissues].

O Yagihashi1, H Ishikawa, S Kitano

  • 1Department of Ophthalmology, School of Medicine, Nihon University, Itabashi-ku, Japan.

Nippon Ganka Gakkai Zasshi
|August 1, 1991
PubMed
Summary
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Zinc levels significantly decrease in the eyes, particularly the retina and choroid, of diabetic NOD mice and zinc-deficient rats. These eye tissues reflect changes in trace element dynamics.

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Nutritional Science

Context:

  • Non-obese diabetic (NOD) mice develop spontaneous diabetes mellitus.
  • Zinc deficiency is a known condition affecting various bodily functions.
  • Eye tissues, including the retina and choroid, have specific metabolic requirements.

Purpose:

  • To investigate the dynamics of trace elements, specifically zinc, in the eye tissues of NOD mice and zinc-deficient rats.
  • To compare zinc levels and uptake in ocular tissues versus other organs in these models.
  • To determine if eye tissues serve as sensitive indicators of systemic trace element imbalances.

Summary:

  • Zinc content was significantly reduced in the retina and choroid of both NOD mice and zinc-deficient rats.
  • Zinc uptake was also diminished in these specific eye tissues compared to other organs studied.

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  • The findings indicate that ocular tissues, particularly the retina and choroid, are highly sensitive to alterations in trace element metabolism.

    • Impact:

    • Highlights the vulnerability of the retina and choroid to zinc deficiency and diabetes.
    • Suggests potential diagnostic value of monitoring zinc levels in eye tissues.
    • Provides insights into the pathogenesis of ocular complications in diabetes and zinc deficiency.