Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Development of the Oral Microbiota

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Maternal and fetal HLA heterozygosity in preeclampsia: Insights from a large multi-ancestry pregnancy cohort.

medRxiv : the preprint server for health sciences·2026

Same author

Associations of per- and polyfluoroalkyl substances (PFAS) exposure and thyroid hormone concentration during pregnancy in the LIFECODES cohort.

International journal of hygiene and environmental health·2026

Same author

Early pregnancy oxylipin markers of inflammation and oxidative stress are associated with small-for-gestational-age birth and specific phenotypes of fetal growth restriction.

American journal of obstetrics and gynecology·2026

Same author

Exposure to organophosphate esters and trajectories of gestational weight gain: A large prospective cohort study.

Environmental research·2026

Same author

Obstetric History Versus Biomarkers: Hypertension Risk Up to 15 Years Postpartum.

Hypertension (Dallas, Tex. : 1979)·2026

Same author

Associations between prenatal per- and polyfluoroalkyl substances (PFAS) exposure and fetal growth measurements in utero and at birth in the LIFECODES cohort: 2006-2019.

Environmental research·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Invited commentary: Intrauterine epidemiology.

Thomas F McElrath¹, Jonathan L Hecht

¹Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. tmcelrath@partners.org

American Journal of Epidemiology

|June 11, 2009

Summary

Investigating preterm birth requires understanding the intrauterine environment. New histology methods reveal 5 vascular constructs at the maternal-placental interface, linked to delivery outcomes and gestational age.

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Related Experiment Videos

Last Updated: Jun 22, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

Perinatal Epidemiology
Reproductive Biology
Pathology

Background:

Traditional preterm birth research relies on maternal clinical presentation, which may not reflect underlying causes.
Understanding the intrauterine and maternal systemic environment is crucial for identifying preterm birth etiologies.
Previous studies have not fully explored the vascular biology of the maternal-placental interface in preterm delivery.

Discussion:

Kelly et al. introduce a histology-based classification of vascular conditions at the maternal-placental interface.
Five distinct vascular constructs were identified, each with specific associations with maternal and fetal vascular pathology.
The frequency of these constructs varies by delivery indication and gestational age, indicating complex intrauterine conditions.

Key Insights:

The study highlights that intrauterine conditions contributing to preterm birth are more complex than previously understood.
A histology-based approach provides a novel perspective on the epidemiology of preterm birth.
The findings suggest a link between specific vascular pathologies and preterm delivery outcomes.

Outlook:

Replication of the described histological technique is essential for validation.
This work pioneers an "intrauterine" perspective in perinatal epidemiology.
Further research can build upon this classification to elucidate preterm birth etiologies and inform clinical practice.