[Prospects for targeted therapy for gliomas].

Area of Science:

• Oncology
• Immunotherapy
• Nanotechnology

Context:

• High-grade gliomas represent aggressive brain tumors with limited treatment options.
• Targeted therapies aim to improve treatment efficacy and reduce systemic toxicity.

Purpose:

• To review current and emerging targeted treatment strategies for high-grade gliomas.
• To analyze the potential of radioimmune therapy and novel approaches.

Summary:

• Radioimmune therapy utilizes monoclonal antibodies targeting tumor-specific antigens like nucleoproteins, matrix proteins, and growth factor receptors.
• Emerging techniques include inactivating critical signaling pathways, boron neutron capture therapy, and employing biomimetic protein vectors for targeted nanoparticle delivery.

Impact:

• This review provides insights into innovative therapeutic avenues for high-grade gliomas.
• It highlights the potential of precision medicine in neuro-oncology.