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Updated: Jun 22, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
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Published on: March 24, 2015

[HLA-E molecule induction on the surface of tumor cells protects them from cytotoxic lymphocytes]

A E Berezhnoĭ, A D Chernisheva, I R Zakeeva

    Voprosy Onkologii
    |June 12, 2009
    PubMed

    Modern immunotherapy has developed powerful tools for mounting antitumor response which nevertheless have had only limited success in clinic. Tumor cells use different mechanisms to escape from immune system. Thus, one of the reasons of unsuccessful immunotherapy might be induction of tolerance of tumor-specific cytotoxic lymphocytes by tumor cells. Previously we have demonstrated expression of HLA-E molecule by the cells of melanoma cell lines. In this paper we have studied HLA-E-dependent mechanism of melanoma cell escape from immune response.

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