[Changes in lipid metabolic parameters in patients with severe sepsis]

The vital importance of systemic inflammatory reactions in developing a critical condition of any etiology is generally accepted at the present developmental stage of reanimatology and intensive care. The metabolic component remains a less studied part of a complex of the universal pathophysiological changes that characterize a critical condition. Lipid metabolic changes in sepsis are less investigated. Some publications indicate a role of fatty acids in regulating a systemic inflammatory reaction and in maintaining the balance of pro- and anti-inflammatory reactions in the development of a systemic inflammatory reaction. Others show their role in endothelial damage. The latter are of great interest due to the fact that lipolysis occurs just on the endothelium with the involvement of lipases. The purpose of this study was to reveal lipid metabolic changes and to define an association between the lipid metabolic parameters and the severity of a systemic inflammatory reaction in patients with severe sepsis, as well as their possible impact on the outcome of the critical condition.