Related Experiment Video
Updated: Apr 26, 2026

Cecal Ligation Puncture Procedure
Published on: May 7, 2011
[Changes in lipid and carbohydrate metabolism in patients with severe sepsis of different etiology]
Unlabelled:
Different origin (heterogeneity) of sepsis is a key stone in many discussions regarding options for the course and outcome, despite the general rules of development of the pathogenic mechanisms.
Purpose Of The Study:
To compare data of systemic inflammation (CRP, PCT, IL-8, IL-6, IL-4, TNF-alpha) and markers of endothelial dysfunction (NO, lactate, D-dimers), also lipid (cholesterol, triglycerides, HDL, LDL, VLDL) and carbohydrate metabolism between the two groups of patients with severe intra-abdominal infection (n = 109) and severe sepsis of other etiologies (n = 53).
Results:
We found out a significant difference between the groups in serum levels of the CRP, IL-4 and cholesterol at all stages of the study. During severe abdominal sepsis was accompanied by a significantly higher level of cholesterol, LDL and VLDL, as well as higher values of glycaemia. Patients with sepsis other etiology showed a lighter and more dynamic course of the disease was significantly lower 28-day mortality.
Related Concept Videos
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Acute Pancreatitis II: Pathophysiology
Lipid Catabolism
Diabetic Ketoacidosis ll: Pathophysiology
Acute Inflammation II: Local and Systemic Effects
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

