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[Radiation recall dermatitis after oral cyclophosphamide].

C Mievis¹, N Jansen, F Schleich

¹Service de Radiothérapie, CHU de Liège, Belgique.

Revue Medicale De Liege

|June 12, 2009

Summary

Radiation recall dermatitis, an inflammatory skin reaction, can be triggered by oral cyclophosphamide. This case report highlights a novel association between this chemotherapy agent and radiation recall dermatitis in prostate cancer patients.

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Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Radiation recall dermatitis (RRD) is an acute inflammatory skin reaction.
It occurs in a previously irradiated area after administration of certain medications.
Commonly associated agents include chemotherapy drugs like gemcitabine, taxanes, and anthracyclines.

Observation:

A 50-year-old man with metastatic prostate cancer experienced RRD.
The reaction occurred in a previously irradiated bone metastasis site.
Two separate episodes of RRD were observed following oral cyclophosphamide treatment.

Findings:

Oral cyclophosphamide was identified as the triggering agent for RRD.
RRD manifested 4-5 weeks after palliative radiotherapy.
The condition resolved spontaneously within 6 weeks of cyclophosphamide cessation and supportive care.

Implications:

This is the first reported instance of RRD induced by oral cyclophosphamide.
Clinicians should consider oral cyclophosphamide as a potential cause of RRD.
Awareness of this association may improve patient management and diagnosis.