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Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Updated: Jun 22, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Reasons for non-return to a pediatric weight management program.

Catherine E Kitscha¹, Kim Brunet, Anna Farmer

¹Nutrition Services, Regional Nutrition and Food Services, Alberta Health Services, Edmonton Area, AB, Canada.

Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Dietetique : Une Publication Des Dietetistes Du Canada

|June 12, 2009

Summary

Pediatric weight management programs face challenges with patient retention. Key barriers include scheduling, parking, clinic environment, and educational content relevance for children and families.

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Assessment of Child Anthropometry in a Large Epidemiologic Study

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

Pediatric Nutrition
Public Health
Behavioral Science

Background:

Childhood obesity is a significant public health issue requiring effective interventions.
Understanding barriers to follow-up care is crucial for optimizing pediatric weight management programs.

Purpose of the Study:

To identify parent/caregiver and/or patient reasons for non-return to clinical follow-up.
To inform the development of more effective pediatric weight management interventions.

Main Methods:

A qualitative telephone survey was used to gather data.
The survey focused on parents/caregivers of children (aged 2.5–14.2 years) with low program attendance.
Face validity was confirmed by five pediatric registered dietitians.

Main Results:

Major barriers to program return included physical (scheduling, parking, location) and organizational (clinic environment) factors.
Program educational content, including the focus on individuals versus families and physical activity interventions, also contributed to non-return.
Inappropriateness of information for the child or parent was another identified barrier.

Conclusions:

Effective pediatric weight management requires interventions that build skills within both the child and the family unit.
Incorporating child and family feedback is essential for improving clinical registered dietitian services and program outcomes.