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Updated: Jun 22, 2026

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Published on: February 6, 2021
[Severe bacterial keratitis and activity of fluoroquinolones]
N Mesplié1, J Kérautret, S Léoni
1Service d'Ophtalmologie, Centre Hospitalier Universitaire Pellegrin, Bordeaux, France. sannico@aliceadsl.fr
Aim:
To study the microbiological characteristics of patients with severe bacterial keratitis in Bordeaux, France, as well as the species' resistance to fluoroquinolones.
Methods:
We conducted a retrospective study of 57 patients presenting severe bacterial keratitis over 20 months. The positive bacteriological cultures of the corneal smears, bacteria, and the antibiogram were listed.
Results:
Fifty-seven patients with severe bacterial keratitis were hospitalized from March 2005 to November 2006. Pseudomonas aeruginosa (n=17), Staphylococcus aureus (n=16), and coagulase-negative Staphylococcus (n=10) were the most frequent species. P. aeruginosa was sensitive in 100% of cases to ciprofloxacin, S. aureus was sensitive in 94% of cases to ciprofloxacin, and coagulase-negative Staphylococcus species were sensitive in 100% of cases to ciprofloxacin. No significant different was noted between ciprofloxacin, levofloxacin, and moxifloxacin on the bacteria studied (p>0.05).
Conclusion:
In this study, except for the Streptococcus species, ciprofloxacin was effective against the species responsible for severe bacterial keratitis.
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