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Updated: Jun 22, 2026

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
The Maudsley Obsessive-Compulsive Stimuli Set: validation of a standardized paradigm for symptom-specific provocation
David Mataix-Cols1, Natalia S Lawrence, Sarah Wooderson
1Departments of Psychological Medicine and Psychology, King's College London, Institute of Psychiatry, United Kingdom. d.mataix@iop.kcl.ac.uk
Abstract:
This article describes and further validates a standardized symptom-provocation procedure that combines symptom-specific audio instructions and pictures to reliably provoke different kinds of symptom-specific anxiety in obsessive-compulsive disorder, corresponding to its four major symptom dimensions: contamination/washing, obsessions/checking, hoarding and symmetry/order. The Maudsley Obsessive-Compulsive Stimuli Set has excellent convergent and discriminant validity, and it will be a useful resource for OCD researchers.
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