Dipeptidyl nitrile inhibitors of Cathepsin L
Nabil Asaad1, Paul A Bethel, Michelle D Coulson
1Respiratory & Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK.
Bioorganic & Medicinal Chemistry Letters
|June 12, 2009
Abstract:
A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
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