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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Diffusion-weighted MRI of urinary bladder and prostate cancers
Ozgür Kiliçkesmez1, Tan Cimilli, Ercan Inci
1Department of Radiology, University of Yeditepe School of Medicine, Istanbul, Turkey. okilickesmez@yahoo.com
Diagnostic and Interventional Radiology (Ankara, Turkey)
|June 12, 2009
Summary
Diffusion-weighted imaging (DWI) shows promise for distinguishing urinary bladder and prostate cancers. Apparent diffusion coefficient (ADC) values are significantly lower in cancerous tissues compared to normal ones, aiding in diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Urinary bladder and prostate carcinomas pose significant health challenges.
- Accurate and early diagnosis is crucial for effective treatment and patient outcomes.
- Diffusion-weighted imaging (DWI) offers a non-invasive method for tissue characterization.
Purpose of the Study:
- To assess the feasibility of using diffusion-weighted imaging (DWI) for diagnosing urinary bladder and prostate carcinomas.
- To correlate apparent diffusion coefficient (ADC) values between malignant and normal tissues.
Main Methods:
- 23 patients with diagnosed urinary bladder (14) and prostate (9) carcinomas were included.
- 50 healthy controls with normal imaging findings were used for comparison.
- DWI was performed with b factors of 0, 500, and 1000 s/mm(2) to calculate ADC values.
Main Results:
- Mean ADC values for bladder carcinomas (0.94 +/- 0.18 x 10(-3)mm(2)/s) were significantly lower than normal bladder wall (2.08 +/- 0.22 x 10(-3)mm(2)/s).
- Mean ADC values for prostate carcinomas (1.06 +/- 0.17 x 10(-3)mm(2)/s) were significantly lower than normal prostate tissues (peripheral: 2.07 +/- 0.33; transitional: 1.46 +/- 0.23 x 10(-3)mm(2)/s).
- Statistical analysis revealed significant differences (P < 0.01) in ADC values between cancerous and normal tissues.
Conclusions:
- Apparent diffusion coefficient (ADC) measurement demonstrates potential in differentiating between carcinomas and normal tissues in the urinary bladder and prostate.
- DWI is a feasible imaging technique for the non-invasive diagnosis of these cancers.
- ADC values can serve as a valuable biomarker for distinguishing malignant from benign tissues.
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