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Related Concept Videos

Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
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DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Published on: May 6, 2010

Genome duality.

Silvia Kocanova1, Kerstin Bystricky

  • 1Laboratoire de Biologie Moléculaire Eucaryote, University of Toulouse, CNRS, 31062 Toulouse, France.

Genome Biology
|June 13, 2009
PubMed
Summary
This summary is machine-generated.

This report summarizes the third Marie Curie Conferences and Training Courses meeting on Higher Order Genome Architecture. Experts discussed advancements in understanding genome organization and its functional implications.

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Area of Science:

  • Genomics and Molecular Biology
  • Epigenetics and Chromatin Structure

Background:

  • The meeting focused on Higher Order Genome Architecture, a key area in modern genomics.
  • It was the third event in the Marie Curie Conferences and Training Courses (MC-GARD) series.

Framework:

  • Discussions centered on novel techniques and computational approaches for analyzing genome organization.
  • Exploration of the relationship between 3D genome structure and gene regulation.

Implementation:

  • Presentations covered experimental methods like Hi-C and computational modeling.
  • Case studies illustrating the impact of architectural changes on cellular processes.

Implications:

  • Advancements in understanding gene expression, DNA replication, and disease mechanisms.
  • Future directions in genome architecture research and therapeutic targeting.