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Related Concept Videos

Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Soft tissue sarcomas or intramuscular haematomas?

Sophie Taïeb1, Nicolas Penel, Luc Vanseymortier

  • 1Department of Radiology, Centre Oscar Lambret, 03, rue Frédéric Combemale, BP 307, 59020 Lille Cedex, France. s-taieb@o-lambret.fr

European Journal of Radiology
|June 13, 2009
PubMed
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Clinicians should suspect tumor hemorrhage, not just hematoma, in patients with minimal trauma, even those with hemophilia. Prompt diagnosis via imaging and biopsy is crucial to rule out rare but aggressive sarcomas.

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Area of Science:

  • Oncology
  • Radiology
  • Hematology

Background:

  • Hematomas are common, while sarcomas are rare.
  • Distinguishing between hematomas and tumor-related hemorrhage can be challenging, particularly in patients with hemophilia.
  • Delayed diagnosis of sarcoma can lead to severe consequences.

Purpose of the Study:

  • To highlight the importance of considering hemorrhage into a tumor in the differential diagnosis of soft tissue masses, especially when trauma is absent or minimal.
  • To emphasize the diagnostic challenges and critical need for early sarcoma detection in patients presenting with hematoma-like findings.
  • To underscore the role of advanced imaging and biopsy in differentiating between benign hematomas and malignant sarcomas.

Main Methods:

  • Review of clinical presentation and diagnostic workup for soft tissue masses.
  • Utilization of sonography with Doppler assessment for evaluating vascularity.
  • Application of magnetic resonance imaging (MRI) with contrast administration for detailed tissue characterization.
  • Emphasis on the role of biopsy in definitive diagnosis.

Main Results:

  • Absence or minimal trauma should raise suspicion for hemorrhage into a tumor.
  • Advanced imaging techniques like Doppler sonography and contrast-enhanced MRI are vital for differential diagnosis.
  • Biopsy remains the gold standard for confirming or excluding high-grade sarcoma.

Conclusions:

  • Hemorrhage into a tumor should be considered in cases of apparent hematoma, particularly with minimal or no trauma history, even in hemophilic patients.
  • A high index of suspicion for sarcoma is warranted, and diagnostic uncertainty necessitates biopsy to prevent missed diagnoses.
  • Integrated diagnostic approaches involving clinical assessment, advanced imaging, and histopathology are essential for optimal patient outcomes.