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Updated: Jun 22, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Published on: December 28, 2017

[Clopidogrel resistance].

Yeşim Güray¹, Umit Güray, Sule Korkmaz

¹Türkiye Yüksek Ihtisas Eğitim ve Araştirma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye. yesimguray@gmail.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology

|June 13, 2009

Summary

Clopidogrel resistance, where patients have activated platelets despite treatment, is a significant issue in atherothrombotic diseases. This review explores its mechanisms, clinical impact, and alternative therapies for improved patient outcomes.

Area of Science:

Cardiovascular Medicine
Pharmacology
Hematology

Background:

Platelets are crucial in atherothrombotic diseases like heart attacks and strokes.
Clopidogrel is a widely used antiplatelet medication, often combined with aspirin.
Some patients show reduced effectiveness to clopidogrel, leading to treatment failure.

Purpose of the Study:

To review the mechanisms behind clopidogrel resistance.
To assess the clinical significance of this therapeutic failure.
To explore alternative treatment options for non-responsive patients.

Main Methods:

Literature review of clinical trials and studies on clopidogrel.
Analysis of proposed mechanisms for clopidogrel resistance.
Evaluation of clinical outcomes associated with clopidogrel resistance.

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Main Results:

Clopidogrel resistance is linked to higher rates of morbidity and mortality.
Multiple factors contribute to impaired response to clopidogrel.
Understanding resistance mechanisms is key to identifying alternative therapies.

Conclusions:

Clopidogrel resistance poses a significant clinical challenge in managing atherothrombotic events.
Further research into resistance mechanisms is needed.
Exploring alternative antiplatelet strategies is essential for these patients.