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Updated: Jun 22, 2026
11:06
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Renal vulnerability to drug toxicity.
1Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06520-8029, USA. mark.perazella@yale.edu
Summary
Drug-induced kidney disease is often linked to patient, kidney, or drug-related risk factors. Identifying these vulnerabilities is key to preventing kidney damage from medications and toxins.
Area of Science:
- Nephrology
- Pharmacology
- Toxicology
Background:
- Drug-induced kidney disease (DILD) is a significant clinical concern.
- Patient vulnerability to nephrotoxins is influenced by multiple factors.
- Kidney injury can manifest in various forms, affecting all renal compartments.
Purpose of the Study:
- To elucidate the multifactorial nature of kidney vulnerability to drug-induced injury.
- To categorize the risk factors contributing to drug-induced kidney disease.
- To highlight the importance of recognizing these factors for prevention.
Main Methods:
- Review and categorization of known risk factors for DILD.
- Analysis of how patient-specific, kidney-related, and drug-related factors interact.
- Correlation of risk factors with specific renal injury patterns and clinical syndromes.
Main Results:
- Risk factors for DILD are broadly classified into patient-specific, kidney-related, and drug-related categories.
- These factors can act independently or synergistically to increase nephrotoxicity.
- All kidney compartments are susceptible, leading to syndromes like acute kidney injury, tubulopathies, and chronic kidney disease.
Conclusions:
- Understanding and recognizing risk factors is paramount in mitigating DILD.
- Proactive identification of vulnerable patients can reduce renal complications from drugs.
- A comprehensive approach considering all factor categories is essential for DILD prevention.
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