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A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Does antineoplasm treatment decrease the glomerular filtration rate in children?
Joanna Stefanowicz1, Radosław Owczuk, Danuta Sierota
1Department of Paediatrics, Medical University of Gdansk, Gdansk, Poland. jstefanowicz@amg.gda.pl
Insights
Children treated for nephroblastoma and other solid tumors show reduced kidney filtration. This indicates a higher risk for chronic kidney disease (CKD) and underscores the need for ongoing nephrological monitoring.
Area of Science:
- Pediatric Nephrology
- Pediatric Oncology
- Renal Function Assessment
Background:
- Children with nephroblastoma may experience persistent renal filtration issues post-treatment.
- Assessing long-term renal health in childhood cancer survivors is crucial.
Purpose of the Study:
- To evaluate renal filtration in children treated for nephroblastoma compared to other childhood cancers.
- To test the hypothesis of increased renal filtration disturbance in nephroblastoma survivors.
Main Methods:
- Cross-sectional study of 127 children and young adults.
- Measured serum cystatin C, microalbuminuria, C-reactive protein, and creatinine.
- Assessed estimated glomerular filtration rate (eGFR) using Schwartz and Filler formulas.
Main Results:
- Nephroblastoma and other solid tumor survivors had significantly lower eGFR (Schwartz and Filler formulas) compared to oncohematological disease survivors.
- Statistical significance (p < 0.0001) observed for all eGFR measurements.
Conclusions:
- Children treated for nephroblastoma and other solid tumors exhibit reduced eGFR.
- These patients face an elevated risk of developing chronic kidney disease (CKD).
- Regular nephrological monitoring is essential for this patient group.
Background:
The aim of this cross-sectional study was to test the hypothesis that children diagnosed with nephroblastoma experience increased disturbance in renal filtration even after prompt treatment compared to patients treated for other neoplastic childhood diseases.
Procedures:
Our study included 127 children and young adults, who were successfully treated for nephroblastoma (n = 34), oncohaematological childhood diseases (n = 58), and other solid tumours (n = 35). In each patient, serum levels of cystatin C, microalbuminuria, and C-reactive protein, and serum and urine levels of creatinine were examined, along with a urine analysis. The estimated glomerular filtration rate (eGFR) was assessed using the Schwartz formula and Filler's formula.
Results:
Our studies show that patients who were successfully treated for nephroblastoma and other solid tumours have lower GFR (GFR(Sch) 118 +/- 20, p = 0.00006, and 117 +/- 22, p = 0.00003; GFR(Filler) 99 +/- 17, p = 0.0001, and 104 +/- 21 ml/min/1.73 m(2), p = 0.0002) than children treated for oncohaematological diseases (GFR(Sch) 137 +/- 19, GFR(Filler) 121 +/- 18 ml/min/1.73 m(2)).
Conclusions:
Patients diagnosed with nephroblastoma and other solid tumours have lower eGFR than children with oncohaematological childhood diseases and are at higher risk for developing CKD. This study demonstrates the necessity of nephrological monitoring.
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