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07:07
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Does antineoplasm treatment decrease the glomerular filtration rate in children?
Joanna Stefanowicz1, Radosław Owczuk, Danuta Sierota
1Department of Paediatrics, Medical University of Gdansk, Gdansk, Poland. jstefanowicz@amg.gda.pl
Kidney & Blood Pressure Research
|June 13, 2009
Summary
Children treated for nephroblastoma and other solid tumors show reduced kidney filtration. This indicates a higher risk for chronic kidney disease (CKD) and underscores the need for ongoing nephrological monitoring.
Area of Science:
- Pediatric Nephrology
- Pediatric Oncology
- Renal Function Assessment
Background:
- Children with nephroblastoma may experience persistent renal filtration issues post-treatment.
- Assessing long-term renal health in childhood cancer survivors is crucial.
Purpose of the Study:
- To evaluate renal filtration in children treated for nephroblastoma compared to other childhood cancers.
- To test the hypothesis of increased renal filtration disturbance in nephroblastoma survivors.
Main Methods:
- Cross-sectional study of 127 children and young adults.
- Measured serum cystatin C, microalbuminuria, C-reactive protein, and creatinine.
- Assessed estimated glomerular filtration rate (eGFR) using Schwartz and Filler formulas.
Main Results:
- Nephroblastoma and other solid tumor survivors had significantly lower eGFR (Schwartz and Filler formulas) compared to oncohematological disease survivors.
- Statistical significance (p < 0.0001) observed for all eGFR measurements.
Conclusions:
- Children treated for nephroblastoma and other solid tumors exhibit reduced eGFR.
- These patients face an elevated risk of developing chronic kidney disease (CKD).
- Regular nephrological monitoring is essential for this patient group.
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