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Updated: Jun 22, 2026
Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
[Expression of transforming growth factor beta1 in human vocal fold polyps]
Tao Liu1, Ping Wu, Mingxiu Zheng
1Department of Otolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming, 650101, China.
Objective:
To analyze the expression of transforming growth factor-beta1 (TGF-beta1) in human vocal fold polyps, and explore the pathogenesis of vocal fold polyp.
Method:
The expression of TGF-beta1 were detected in 37 examples of vocal fold polyps and 11 healthy vocal folds by immunohistochemical staining (SP method). Meanwhile, the positive results were compared.
Result:
The percent of positive expression of TGF-beta1 was 56.76% and the number of positive cells was 22.55 +/- 27.31 in vocal fold polyps, both of which were significantly increased compared with the percent of positive expression of TGF-beta1 (18.18%) and the number of positive cells (2.53 +/- 3.75) in healthy vocal folds (P<0.05). The positive expression of TGF-beta1 in stroma cells of vocal cord polyps was significantly higher than that in the healthy vocal cords. There was no significant difference of TGF-beta1 between the vocal fold polyps of male and female (P>0.05).
Conclusion:
TGF-beta1 may participate in some pathologic changes in vocal cord polyps, such as extracellular matrix accumulation, local fibrosis and formation and development of vocal cord polyps. Manipulating the TGF-beta1 expression in vocal cord polyps may supply a new treatment method.
