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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jun 22, 2026

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
09:26

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

Published on: July 29, 2011

Circulating endothelial progenitor cells in malignant gliomas.

Neysan Rafat1, Grietje Ch Beck, Jutta Schulte

  • 1Department of Anaesthesiology and Critical Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany.

Journal of Neurosurgery
|June 16, 2009
PubMed
Summary

Circulating endothelial progenitor cells (cEPCs) are elevated in patients with malignant gliomas, correlating with tumor angiogenesis. These findings suggest cEPCs could be a biomarker for identifying patients suitable for antiangiogenic therapy.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

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Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
09:26

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Published on: July 29, 2011

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Area of Science:

  • Neuro-oncology
  • Vascular Biology
  • Biomarker Discovery

Background:

  • Malignant gliomas exhibit increased angiogenesis, involving recruitment of circulating endothelial progenitor cells (cEPCs).
  • Elevated cEPC levels are proposed as a potential biomarker for glioma diagnosis and monitoring.

Purpose of the Study:

  • To investigate cEPC levels and associated mobilizing mediators in patients with malignant gliomas.
  • To determine the correlation between cEPC levels and glioma angiogenesis.

Main Methods:

  • Quantified cEPCs using flow cytometry (CD34, CD133, VEGFR-2) in patients with glioblastoma multiforme (GBM), brain metastases, and healthy volunteers.
  • Measured serum VEGF and GM-CSF concentrations via ELISA.
  • Assessed tumor blood vessel density using CD34 immunohistochemistry.

Main Results:

  • Significantly higher cEPC counts were observed in GBM patients compared to those with metastases or healthy controls.
  • Elevated serum VEGF and GM-CSF levels were found in GBM and metastasis patients.
  • Higher cEPC levels in GBM patients correlated with increased tumor blood vessel density.

Conclusions:

  • cEPCs are mobilized in malignant gliomas and correlate with angiogenic activity.
  • cEPCs show potential as a novel biomarker for identifying GBM patients who may benefit from antiangiogenic therapies.