Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Pituitary Gland01:17

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-invasive assessment of muscle compartment elasticity by pressure-related ultrasound in pediatric trauma: a prospective clinical study in 25 cases of forearm shaft fractures.

European journal of medical research·2023
Same author

Djeho, the Egyptian God's dancer with dwarfism from the thirtieth dynasty.

Journal of endocrinological investigation·2023
Same author

[How to explore... hyperandrogenism associated with insulin resistance ? An example based on the HAIR-AN syndrome.]

Revue medicale de Liege·2021
Same author

An Infundibular Unidentified Object (IUO): a new pituitary stalk marker?

Pituitary·2021
Same author

[Neuroendocrine neoplasms : a new era to the top of multidisciplinarity !]

Revue medicale de Liege·2021
Same author

[Polycystic ovary syndrome : the advantages of multidisciplinary management].

Revue medicale de Liege·2020

Related Experiment Video

Updated: Jun 22, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Familial pituitary adenomas.

M A Tichomirowa1, A F Daly, A Beckers

  • 1Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège 4000, Belgium.

Journal of Internal Medicine
|June 16, 2009
PubMed
Summary

Familial pituitary adenomas, including FIPA, present unique clinical features and diverse genetic causes. Research highlights AIP gene mutations in FIPA, suggesting complex genetic underpinnings for these rare tumors.

More Related Videos

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
08:31

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
12:34

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome

Published on: April 2, 2018

Related Experiment Videos

Last Updated: Jun 22, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
08:31

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
12:34

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome

Published on: April 2, 2018

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Pituitary adenomas are typically sporadic, but 5% have a familial basis.
  • Familial cases include Multiple Endocrine Neoplasia type 1 (MEN-1), Carney's Complex (CNC), and Familial Isolated Pituitary Adenomas (FIPA).
  • FIPA encompasses all pituitary tumor phenotypes not linked to MEN-1 or CNC.

Purpose of the Study:

  • To review the clinical characteristics, tumor pathologies, and genetic data of familial pituitary adenomas.
  • To differentiate FIPA from sporadic pituitary adenomas and other familial syndromes.
  • To highlight the genetic heterogeneity of FIPA, including AIP gene mutations.

Main Methods:

  • Literature review of familial pituitary adenoma cases.
  • Analysis of clinical presentations and tumor pathologies.
  • Summary of genetic and molecular findings, focusing on AIP mutations.

Main Results:

  • FIPA patients are diagnosed younger and have larger tumors than sporadic cases.
  • Approximately 15% of FIPA cases harbor mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.
  • Familial pituitary adenomas exhibit diverse genetic etiologies beyond MEN-1 and CNC.

Conclusions:

  • Familial pituitary adenomas represent a distinct clinical and genetic entity.
  • FIPA is characterized by specific clinical features and a diverse genetic landscape.
  • Further research into the genetic pathophysiology of FIPA is warranted.