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Related Experiment Video

Updated: Jun 22, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Giant cell arteritis on 18F-FDG PET/CT.

Thomas F Heston¹, Zsolt Szabo

¹Johns Hopkins Nuclear Medicine, Baltimore, MD 21287, USA.

Clinical Physiology and Functional Imaging

|June 16, 2009

Summary

Positron emission tomography/computed tomography (PET/CT) can incidentally detect giant cell arteritis. Increased 18F-fluorodeoxyglucose (FDG) uptake in the aorta on PET/CT scans may indicate this condition.

Area of Science:

Nuclear Medicine
Vascular Imaging
Oncology

Background:

18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a key imaging modality for cancer staging.
Incidental findings during PET/CT can reveal significant comorbidities.

Observation:

A patient undergoing PET/CT for renal transitional cell carcinoma staging exhibited diffuse 18F-FDG uptake in the aorta and proximal arteries.
CT images revealed a thickened aortic wall, prompting further investigation.

Findings:

Biopsy confirmed giant cell arteritis in the patient.
The imaging findings correlated with biopsy-proven giant cell arteritis.

Implications:

Increased aortic FDG uptake on PET/CT can be an indicator of giant cell arteritis, a potentially serious vascular condition.

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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

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Routine evaluation of aortic uptake in 18F-FDG PET/CT scans is recommended to identify important comorbidities in cancer patients.

This case highlights the value of PET/CT in detecting non-oncologic conditions alongside cancer staging.