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Optimization of Performance Parameters of the TAGGG Telomere Length Assay
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Label-free detection of specific DNA sequence-telomere using unmodified gold nanoparticles as colorimetric probes

Yingying Qi1, Li Li, Baoxin Li

  • 1Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|June 16, 2009
PubMed

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...