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Related Concept Videos

Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Hydraulic Jump01:29

Hydraulic Jump

A hydraulic jump is a sudden rise in fluid depth in open channels, occurring when high-velocity (supercritical) flow transitions to low-velocity (subcritical) flow. This phenomenon requires an upstream Froude number greater than 1, as flows with Fr1<1 remain subcritical, making a hydraulic jump impossible due to the need for negative head loss, which violates thermodynamic principles.The characteristics of a hydraulic jump depend on the upstream Froude number and are classified as...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cohesion01:07

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
Rolling With Slipping01:14

Rolling With Slipping

Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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Updated: Jun 22, 2026

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Adhesion dance with raver.

Tobias Madl1, Michael Sattler

  • 1Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

Structure (London, England : 1993)
|June 16, 2009
PubMed
Summary
This summary is machine-generated.

Spatial control of gene expression is achieved by localizing messenger RNAs (mRNAs) to specific cell parts. New crystal structures reveal how raver1-vinculin may facilitate mRNA localization during focal adhesion assembly.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Structural Biology

Background:

  • Messenger RNA (mRNA) localization is crucial for spatial control of gene expression within cells.
  • Focal adhesions are key cellular structures involved in cell adhesion and migration.
  • Understanding the mechanisms of mRNA localization is essential for deciphering cellular organization.

Purpose of the Study:

  • To propose a mechanism for mRNA localization during focal adhesion assembly.
  • To investigate the role of raver1-vinculin interaction in this process.

Main Methods:

  • X-ray crystallography to determine the structure of raver1-vinculin complex.
  • Structural analysis to infer functional mechanisms.

Main Results:

  • Crystal structures of raver1-vinculin complex were determined.
  • The structures suggest a potential role for raver1-vinculin in facilitating mRNA localization.
  • This interaction may occur during the dynamic assembly of focal adhesions.

Conclusions:

  • The raver1-vinculin interaction provides a structural basis for a potential mRNA localization mechanism.
  • This finding offers insights into the spatial regulation of gene expression at focal adhesions.