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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Left ventricular diastolic filling pressures during dobutamine stress echocardiography: relationship to symptoms and

Yoshie Nakajima1, Garvan C Kane, Robert B McCully

  • 1Division of Cardiovascular Diseases and the Mayo Clinic, Rochester, MN 55905, USA.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|June 16, 2009
PubMed

Insights

Dobutamine stress echocardiography (DSE) reveals that increased E/e' ratios are linked to myocardial ischemia and symptoms. This finding highlights the association between diastolic dysfunction and stress-induced cardiac events during DSE.

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Echocardiography

Background:

  • Limited data exists on left ventricular diastolic filling parameters during dobutamine stress echocardiography (DSE).
  • The relationship between Doppler-derived diastolic function and stress-induced symptoms or myocardial ischemia is not well-defined.

Purpose of the Study:

  • To investigate the association between Doppler parameters of left ventricular diastolic filling and the occurrence of symptoms and ischemic wall motion abnormalities during DSE.
  • To determine if diastolic dysfunction indicators predict ischemia during stress testing.

Main Methods:

  • Prospective study of 219 patients undergoing clinically indicated DSE.
  • Pulsed-wave Doppler measurements of mitral inflow and annular tissue velocities were recorded at baseline, during stress, and recovery.
  • Patients were categorized based on the presence (n=70) or absence (n=149) of stress-induced ischemia.

Main Results:

  • Patients with ischemia exhibited lower baseline and peak stress diastolic annular tissue velocities (e').
  • The E/e' ratio was significantly higher at peak stress and during recovery in patients with ischemia.
  • An increased E/e' ratio from stress to recovery and symptom development were independently associated with ischemia.

Conclusions:

  • The development of symptoms and myocardial ischemia during DSE are associated with an elevated E/e' ratio.
  • Further research is needed to clarify the prognostic significance of increased E/e' during DSE.
Abstract

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