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Published on: February 2, 2024
Bioactive constituents from the stems of Dalbergia parviflora
Uraiwan Songsiang1, Suchana Wanich, Siripit Pitchuanchom
1Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Abstract:
From the stems of Dalbergia parviflora, three known flavonoids, six known isoflavonoids, a new isoflavone, dalparvone (2) and a new cinnamyl derivative, dalparvinene (6) were isolated and characterized. Isoflavan 3 exhibited strong cytotoxicity against KB and NCI-H187 cell lines with IC(50) values of 0.53 and 2.04 microg/ml, respectively. Compound 6 demonstrated strong cytotoxicity against NCI-H187 with an IC(50) value of 1.46 microg/ml. Compounds 4 and 6 possessed moderate cytotoxicity against KB cells with IC(50) values of 6.78 and 9.89 microg/ml, respectively. In addition, 2 exhibited moderate antiplasmodial activity with an IC(50) value of 8.19 microg/ml.
