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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Erectile dysfunction in systemic sclerosis.

U A Walker1, A Tyndall, R Ruszat

  • 1Department of Rheumatology, Basel University, Basel, Switzerland. ulrich.walker@fps-basel.ch

Annals of the Rheumatic Diseases
|June 16, 2009
PubMed
Summary
This summary is machine-generated.

Erectile dysfunction (ED) affects up to 81% of men with systemic sclerosis (SSc). While ED in SSc has unique causes, treatments like PDE-5 inhibitors and penile implants offer limited to significant benefits.

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Area of Science:

  • Rheumatology
  • Urology
  • Cardiovascular Medicine

Background:

  • Erectile dysfunction (ED) is highly prevalent in men with systemic sclerosis (SSc), affecting up to 81% of this population.
  • Unlike the general population where ED is often linked to atherosclerosis, SSc-related ED stems from distinct pathophysiological mechanisms.

Purpose of the Study:

  • To elucidate the unique etiology of ED in systemic sclerosis.
  • To review current and potential therapeutic strategies for managing ED in SSc patients.
  • To highlight the importance of addressing ED as a common complication in SSc.

Main Methods:

  • Review of existing literature on ED in systemic sclerosis.
  • Analysis of the pathophysiology of ED specific to SSc, including vascular and fibrotic changes.
  • Evaluation of treatment efficacy for ED in SSc, including phosphodiesterase type 5 (PDE-5) inhibitors and intracavernosal injections.

Main Results:

  • Systemic sclerosis impairs penile blood flow through myointimal proliferation of small arteries and corporal fibrosis.
  • On-demand PDE-5 inhibitors show limited efficacy, while regular, long-acting PDE-5 inhibitor regimens offer some clinical benefit.
  • Intracavernosal prostaglandin E1 injections may be considered, with penile prosthesis implantation as a subsequent option for refractory cases.

Conclusions:

  • ED is a significant and common complaint in men with systemic sclerosis, requiring specific clinical consideration.
  • Treatment approaches for SSc-related ED differ from those for atherosclerotic ED, with varied levels of effectiveness.
  • Management of complex ED cases in SSc may necessitate specialized urological intervention.