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Updated: Jun 22, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Family burden in bipolar disorders: results from the Italian Mood Disorders Study (IMDS)
Lorenza Magliano1, Ada Orrico, Andrea Fiorillo
1Department of Psychiatry, University of Naples SUN, Naples, Italy. lorenza.magliano@unina2.it
Aims:
To explore: a) the burden of care, and the professional and social support in relatives of patients with bipolar disorders; b) the psychosocial interventions provided to patients and their families by Italian mental health centres.
Methods:
342 outpatients with a bipolar disorder and their key-relatives were randomly recruited in 26 Italian mental health centres, randomly selected and stratified by geographical area and population density. Family burden was explored in relation to: a) patient's clinical status and disability; b) relatives' social and professional support; c) interventions received by patients and their families; d) geographical area.
Results:
In the previous two months, global functioning was moderately impaired in 36% of the patients, and severely impaired in 34% of them. Twenty-one percent of patients attended a rehabilitative programme, and 3% of their families received a psychoeducational intervention. Burden was higher when patient's symptoms and disability were more severe, the relatives had poorer psychological support and help in emergencies by the social network, and the family lived in Southern Italy. Differences in family burden in relation to geographical area disappeared when psychosocial interventions were provided.
Conclusion:
This study highlights the need to increase the availability of rehabilitative interventions for patients with bipolar disorders and of psychological support for their families, especially in Southern Italy.
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