Related Experiment Video
Updated: Aug 5, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Postpartum Suicidality beyond Depression: a Systematic Review of Risk Profiles and Prevention Gaps
Valentina Baldini1,2, Martina Gnazzo3, Giorgia Varallo2
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Postpartum suicidality is common and linked to factors beyond depression, including anxiety and trauma. Broader screening is needed to identify at-risk mothers for better prevention and intervention.
Area of Science:
- Perinatal mental health
- Public health
- Psychiatry
Background:
- Suicidal ideation and behavior in the postpartum period contribute significantly to maternal morbidity and mortality.
- Postpartum depression is a known risk factor, but suicidality can occur independently, leading to underrecognition.
Purpose of the Study:
- To systematically review the prevalence of postpartum suicidal ideation and behavior.
- To identify associated risk factors beyond postpartum depression.
Main Methods:
- Systematic literature search of major databases (PubMed, Web of Science, EMBASE, PsycINFO) up to March 2025.
- PRISMA guidelines followed for study selection.
- Inclusion of 20 studies with 352,726 postpartum women.
Main Results:
- Prevalence of suicidal ideation varied widely (2.2% to >50%) based on population and assessment.
- Key risk factors included postpartum depression, anxiety, trauma history, intimate partner violence, unplanned pregnancy, low socioeconomic status, low social support, and adverse childhood experiences.
- Suicidal ideation was reported even without clinical depression, highlighting a multifactorial etiology.
Conclusions:
- Postpartum suicidality is complex and not solely explained by depression.
- Expanded screening incorporating psychosocial and trauma factors is crucial.
- Trauma-informed, integrated approaches are recommended for early identification and prevention.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Bulimia Nervosa
Depression: Overview
Psychological and Sociocultural Causes of Schizophrenia
Bipolar Disorder
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...