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[Effects of astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary

Zhu-Ling Qu1, He Dong, Shi-Duan Wang

  • 1Department of Anesthesiology, The Affiliated Hospital of Medical College, Qingdao University, Shandong. quzhuling@163.com

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|June 17, 2009
PubMed

Insights

Astragalus Injection (AI) administration during cardiopulmonary bypass (CPB) surgery helps protect kidney function. This study found AI reduced markers of renal injury in patients undergoing cardiac valve replacement, suggesting a protective effect against CPB-induced renal impairment.

Area of Science:

  • Cardiovascular Surgery
  • Nephrology
  • Pharmacology

Background:

  • Cardiac valve replacement often involves cardiopulmonary bypass (CPB), a procedure associated with increased risk of perioperative kidney injury.
  • Early detection and prevention of renal dysfunction are crucial for improving patient outcomes after CPB.

Purpose of the Study:

  • To evaluate the efficacy of Astragalus Injection (AI) in preserving renal function in patients undergoing cardiac valve replacement with CPB.
  • To assess the impact of AI on specific biomarkers of kidney damage and function.

Main Methods:

  • A randomized controlled trial involving 40 patients undergoing cardiac valve replacement with CPB.
  • Patients were assigned to receive either AI or Ringer's Lactate (control) perioperatively.
  • Renal function was monitored by measuring serum and urinary levels of BUN, creatinine, beta2-microglobulin, microalbumin, and NAG at various time points.

Main Results:

  • The control group showed significant increases in BUN, creatinine, and urinary markers of kidney injury post-CPB.
  • Patients receiving AI exhibited significantly lower levels of serum creatinine and BUN, and reduced urinary beta2-MG, microalbumin, and NAG compared to the control group.
  • AI administration was associated with a protective effect against CPB-induced renal impairment.

Conclusions:

  • Cardiopulmonary bypass can induce renal dysfunction.
  • Perioperative administration of Astragalus Injection demonstrates a protective effect on renal function in patients undergoing cardiac valve replacement with CPB.
Abstract

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