Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

Binary Fission

Binary Fission

Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.

Binary Fission

Binary Fission

Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...

Replication in Prokaryotes

Replication in Prokaryotes

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multifaceted effects of N-glycosylation on amyloidogenic κ light chains in AL amyloidosis.

Structure (London, England : 1993)·2026

Same author

Exploring light chain cardiotoxicity in AL amyloidosis: impact on hiPSC-derived cardiomyocyte activity.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2026

Same author

Unveiling the unseen: navigating heart involvement in amyloidosis with biomarkers beyond the horizons of imaging.

European heart journal. Imaging methods and practice·2026

Same author

Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.

Nature communications·2026

Same author

Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.

Gut microbes·2026

Same author

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex.

PLoS pathogens·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Cells and prions: a license to replicate.

Mario Nuvolone¹, Adriano Aguzzi, Mathias Heikenwalder

¹Department of Pathology, Institutes of Neuropathology, University Hospital Zurich, Switzerland.

|June 17, 2009

Summary

Prion diseases involve misfolded prion proteins aggregating in the brain and lymphoid organs. This review explores peripheral prion replication, spread to the brain, and factors influencing prion replication competence.

Area of Science:

Neuroscience
Infectious Diseases
Biochemistry

Background:

Prion diseases are fatal neurodegenerative disorders.
They are caused by misfolded prion proteins (PrPSc).
Prions infect the central nervous system and lymphoid organs.

Purpose of the Study:

To review the current understanding of peripheral prion replication.
To discuss mechanisms of prion neuroinvasion.
To identify factors determining prion replication competence.

Main Methods:

Literature review of prion disease research.
Analysis of studies on extraneural prion replication.
Synthesis of data on neuroinvasion pathways.

More Related Videos

Protein Misfolding Cyclic Amplification of Prions

Protein Misfolding Cyclic Amplification of Prions

Published on: November 7, 2012

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

Related Experiment Videos

Last Updated: Jun 22, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Protein Misfolding Cyclic Amplification of Prions

Protein Misfolding Cyclic Amplification of Prions

Published on: November 7, 2012

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

Main Results:

Prions replicate beyond the central nervous system, notably in follicular dendritic cells.
Evidence suggests a wider range of cell types can support prion replication.
Mechanisms of prion spread to the brain are complex and multifactorial.

Conclusions:

Peripheral prion replication is a significant aspect of prion pathogenesis.
Understanding extraneural prion replication is crucial for developing therapeutics.
Further research is needed to fully elucidate prion replication determinants.