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Updated: Jun 22, 2026

Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice
Published on: September 17, 2015
Changes in the rhythmoinotropic dependence of the myocardium in rats with postinfarction cardiosclerosis after
D S Kondratyeva1, S A Afanasyev, N A Ligacheva
1Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. dina@cardio.tsu.ru
Abstract:
The rhythmoinotropic dependence of the papillary muscles was studied in rats with postinfarction cardiosclerosis after blocking of beta(1)-adrenoreceptors by concor (7 mg/kg daily). The development of postinfarction cardiosclerosis led to a reduction of the postextrasystolic potentiation and of potentiation induced by periods of rest. Preliminary blocking of beta(1)-adrenoreceptors stimulated the postextrasystolic contractions and contractions after periods of rest in the myocardium of rats with postinfarction cardiosclerosis. These results suggest that blocking of beta(1)-adrenoreceptors promotes an improvement of calcium-accumulating function of the cardiomyocyte sarcoplasmatic reticulum in the myocardium of rats with postinfarction cardiosclerosis.
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