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Updated: Jun 22, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Vascular endothelial growth factor gene polymorphisms and pregnancy
George Galazios1, Dimitrios Papazoglou, Panagiotis Tsikouras
1Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. ggalaz@med.duth.gr
Vascular endothelial growth factor (VEGF) gene variations are linked to pregnancy complications like pre-eclampsia and preterm birth. Specific VEGF polymorphisms increase the risk of these conditions and recurrent pregnancy loss.
Area of Science:
- Obstetrics and Gynecology
- Genetics
- Molecular Biology
Background:
- Vascular endothelial growth factor (VEGF) is crucial for blood vessel formation during pregnancy.
- VEGF plays a vital role in trophoblast proliferation and fetal blood cell development.
- Altered VEGF levels are observed in pregnancy disorders like pre-eclampsia and preterm labor.
Purpose of the Study:
- To review the association between VEGF gene polymorphisms and pregnancy complications.
- To highlight the role of VEGF genetic variations in pre-eclampsia, preterm delivery, and recurrent pregnancy loss.
Main Methods:
- Literature review of studies investigating VEGF gene polymorphisms and pregnancy outcomes.
- Analysis of genetic association studies focusing on specific VEGF polymorphisms (e.g., 936C/T, -1154).
Main Results:
- The 936C/T VEGF gene polymorphism shows a significant correlation with pre-eclampsia severity.
- This polymorphism is associated with an increased risk of spontaneous preterm delivery, particularly in homozygotes.
- The -1154 allele of the VEGF gene is linked to an elevated risk of recurrent pregnancy loss.
Conclusions:
- VEGF gene polymorphisms are implicated in the pathophysiology of several pregnancy disorders.
- Further genetic research is necessary to validate these findings and understand the underlying mechanisms.
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