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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth
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Published on: February 9, 2012

Characterization of engineered tissue construct mechanical function by magnetic resonance imaging.

C P Neu1, H F Arastu, S Curtiss

  • 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA. cpneu@purdue.edu

Journal of Tissue Engineering and Regenerative Medicine
|June 17, 2009
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) non-invasively assesses engineered tissue mechanics. Advanced MRI phase contrast methods reveal non-uniform strain and glycosaminoglycan distribution, crucial for tissue regeneration.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Tissue Engineering

Background:

  • Engineered tissues require mechanical function assessment for successful regeneration.
  • Articular cartilage, spine, and heart regeneration rely on mechanical endpoints.
  • Non-invasive magnetic resonance imaging (MRI) characterizes tissue physical phenomena.

Purpose of the Study:

  • To demonstrate MRI application for characterizing engineered tissue mechanical function.
  • To utilize phase contrast-based MRI for detailed deformation field analysis.
  • To correlate mechanical properties with extracellular matrix composition.

Main Methods:

  • Applied phase contrast-based MRI to an articular cartilage defect model.
  • Characterized detailed deformation fields within native and engineered tissues.
  • Assessed glycosaminoglycan ([GAG]) concentration using gadolinium-enhanced MRI.

Main Results:

  • MRI revealed non-uniform strain fields varying with spatial position.
  • Tissue constructs exhibited higher strains than surrounding native cartilage.
  • [GAG] concentration was lowest in tissue constructs and varied spatially.

Conclusions:

  • MRI provides complementary data on tissue mechanical function.
  • Deformation relates to tissue geometry, extracellular matrix, and integration.
  • Advanced MRI phase contrast methods are valuable for evaluating engineered tissues.