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Updated: Jun 22, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
[Gonadal function in boys prior to treatment for acute lymphoblastic leukaemia]
Maryna Krawczuk-Rybak1, Elzbieta Solarz, Małgorzata Wojtkowska
1Klinika Onkologii i Hematologii Dzieciecej, Uniwersytet Medyczny w Białymstoku, ul. Waszyngtona 17, 15-274 Białystok, Poland. rybak@umwb.edu.pl
Unlabelled:
The aim of this study was to evaluate the gonadal function in boys with newly-diagnosed acute lymphoblastic leukaemia, prior to therapy.
Patients And Methods:
The analysis was evaluated in 48 boys with acute lymphoblastic leukaemia, at the time of diagnosis; 34 boys were prepubertal - Tanner stage of sexual maturation 1 (group I) and 14 - pubertal - Tanner stage 3-5 (group II). Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone and testicular volume were determined.
Results:
In group I no alteration in hormonal status was observed, whereas in group II lower inhibin B was found (68.09 ng/l+/-54.87 vs 152.66 ng/l+/-72.09, p=0.0002). The levels of FSH, LH, testosterone and testicular volume did not differ from healthy adolescents. We did not observe a correlation between inhibin B and FSH concentrations. We did not find the influence of immunophenotype of leukaemic cells, leukocytosis, haemoglobin, platelets levels as well as LDH activity on the values of analyzed hormones.
Conclusion:
In adolescent boys with newly diagnosed leukaemia, lowered inhibin B values may suggest the damage of spermatogenesis even before the start of chemo- and radiotherapy. The small number of examined children requires confirmation on a larger group of patients.
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