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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization

Yutaka Furukawa1, Natsuhiko Ehara, Ryoji Taniguchi

  • 1Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan. furukawa@kcgh.gr.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|June 18, 2009
PubMed

Insights

Young adults with coronary artery disease (CAD) have multiple risk factors. Chronic kidney disease (CKD) is a significant predictor of major cardiovascular events (MACE) in these patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Coronary artery disease (CAD) prevalence is rising among young adults.
  • Identifying risk factors is crucial for preventing heart attacks in younger individuals.
  • This study focuses on the risk profile and predictors of major cardiovascular events (MACE) in young CAD patients.

Purpose of the Study:

  • To analyze the risk factor profile in young CAD patients.
  • To identify predictors of MACE in young CAD patients.
  • To compare risk factors between younger and older CAD patient groups.

Main Methods:

  • Data from the CREDO-Kyoto registry of Japanese patients undergoing first coronary revascularization were analyzed.
  • Patients were divided into younger (≤55 years) and older (>55 years) groups.
  • Multivariate analyses were used to identify predictors of MACE.

Main Results:

  • Younger patients (n=898) had higher prevalence of male sex, obesity, smoking, family history of CAD, dyslipidemia, and metabolic syndrome.
  • Chronic kidney disease (CKD) was the sole significant predictor of MACE in younger patients.
  • CKD also proved to be a significant prognostic factor in older patients.

Conclusions:

  • Multiple risk factors are common in young Japanese patients with CAD.
  • CKD is significantly associated with MACE in young CAD patients.
  • CKD is an important prognostic factor for cardiovascular events in both young and older CAD patients.
Abstract

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