Related Experiment Video
Updated: Jun 22, 2026
11:54
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
Nasosinus mucin expression in normal and inflammatory conditions
1ENT Department, Mansoura University Hospital, Mansoura, Egypt. msamomar@hotmail.com
Current Opinion in Allergy and Clinical Immunology
|June 18, 2009
Summary
Mucin expression in the nose and sinuses is complex and changes with inflammation. Further research is needed to understand the clinical implications of these mucin gene variations.
Area of Science:
- Otorhinolaryngology
- Molecular Biology
- Immunology
Background:
- Mucin expression in the nasosinus mucosa is altered during inflammation.
- The full spectrum of mucin gene expression in the nasosinus mucosa is not yet characterized.
Purpose of the Study:
- To review current knowledge on mucin expression in normal and pathological nasosinus mucosa.
- To highlight the complexity and variations in mucin expression patterns.
Main Methods:
- Literature review of studies on nasosinus mucin expression.
- Analysis of mucin gene expression patterns in normal and inflamed tissues.
Main Results:
- Specific mucin genes (MUC1, 2, 4, 5AC, 5B, 8) are upregulated in inflamed nasosinus mucosa.
- Nasosinus submucosal glands are more significant in mucin production than surface epithelium.
- Current research is primarily basic science; clinical implications remain unclear.
Conclusions:
- Nasosinus mucin expression is highly complex and variable.
- Large-scale studies are required to elucidate the role of physiological and pathological factors, including inflammatory mediators.
- Understanding these factors is crucial for future therapeutic applications in nasosinus conditions.
Related Concept Videos
01:24Nose and Nasal Cavity
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
01:29Microbiota of the Respiratory Tract
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
01:16Drugs Used in Upper Respiratory Disorders: Overview
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...