Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Burst-Learning Electrocardiogram Curriculum for Internal Medicine Residents: A Single-Center Quality Improvement Initiative.

JACC. Case reports·2026
Same author

Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension: The Launch-HTN Randomized Clinical Trial.

JAMA·2025
Same author

Abdominal Compared With Coronary Artery Calcification and Incident Cardiovascular Events and Mortality in Black Adults.

Circulation. Cardiovascular imaging·2024
Same author

COVID-19 Prevention and Mitigation Decision-Making Processes While Navigating Chronic Disease Care: Perspectives of Black Adults with Heart Failure and Diabetes.

Journal of racial and ethnic health disparities·2024
Same author

Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome.

Expert opinion on pharmacotherapy·2024
Same author

Carotid Intima-Media Thickness and Improved Stroke Risk Assessment in Hypertensive Black Adults.

American journal of hypertension·2024
Same journal

Contemporary medical management of left ventricular assist device patients: integrating sex-specific perspectives.

Current opinion in cardiology·2026
Same journal

Viability testing for guiding revascularization in ischemic cardiomyopathy.

Current opinion in cardiology·2026
Same journal

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

Current opinion in cardiology·2026
Same journal

Rebooting blood vessel repair: implications of the SEMA-VR CardioLink-15 trial.

Current opinion in cardiology·2026
Same journal

Advancements in wearable technology for heart failure patients.

Current opinion in cardiology·2026
Same journal

Minimally invasive approaches to coronary artery bypass grafting: techniques, current evidence, and future directions.

Current opinion in cardiology·2026
See all related articles

Related Experiment Videos

Anemia and heart failure.

Jalal K Ghali1

  • 1Harper University Hospital, 3990 John R Street, 9 Webber Core, Detroit, MI 48201, USA. jghali@dmc.org

Current Opinion in Cardiology
|June 18, 2009
PubMed
Summary
This summary is machine-generated.

Erythropoiesis-stimulating agents (ESAs) and iron replacement show potential benefits for heart failure patients with anemia. Ongoing studies will determine their definitive role in treatment.

Related Experiment Videos

Area of Science:

  • Cardiology
  • Hematology
  • Pharmacology

Background:

  • Anemia is common in heart failure and linked to poor outcomes.
  • Previous enthusiasm for erythropoiesis-stimulating agents (ESAs) has been tempered by safety concerns.

Purpose of the Study:

  • To review the current evidence on anemia management in heart failure.
  • To assess the safety and efficacy of ESAs and iron replacement in this population.

Main Methods:

  • Review of recent clinical studies and trials.
  • Analysis of data regarding anemia prevalence, prognostic significance, and treatment effects.

Main Results:

  • Recent studies confirm anemia's high prevalence and prognostic importance in heart failure.
  • ESAs show encouraging safety signals and potential non-hematopoietic benefits.
  • Iron replacement may also offer benefits in heart failure.

Conclusions:

  • Preliminary data suggest potential benefits of ESAs and iron for heart failure patients.
  • Further randomized placebo-controlled trials are necessary to establish the definitive role of these interventions.