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Updated: Jun 22, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

A chip-to-chip nanoliter microfluidic dispenser.

Jianbin Wang¹, Ying Zhou, Haiwei Qiu

¹Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing, 100871, China. yanyi@pku.edu.cn

|June 18, 2009

Summary

A novel microfluidic device precisely dispenses nanoliter volumes, preventing cross-contamination. This high-throughput system offers flexibility for large-scale screening and polymerase chain reaction (PCR) applications.

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Area of Science:

Biotechnology
Microfluidics
Analytical Chemistry

Background:

High-throughput screening requires precise liquid handling at low volumes.
Existing methods often face challenges with cross-contamination and limited flexibility.

Purpose of the Study:

To develop a high-throughput microfluidic device for accurate nanoliter liquid dispensation.
To demonstrate the system's capability in preventing cross-contamination for large-scale experiments.

Main Methods:

Development of a novel microfluidic device for liquid handling.
Implementation of a nanoliter dispensing system.
Testing for cross-contamination between microwells.

Main Results:

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Last Updated: Jun 22, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells

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The microfluidic dispenser successfully handled liquid dispensation in the nanoliter range.

The system demonstrated no cross-contamination between microwells.

An array of 115 nl polymerase chain reaction (PCR) reactions was performed, showcasing system flexibility.

Conclusions:

The developed microfluidic device is a highly flexible and versatile tool for nanoliter liquid handling.
The system shows significant potential for large-scale screening and various molecular biology applications.