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Updated: Aug 11, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
Published on: January 31, 2013
Upper extremity contractures in a patient with eosinophilia-myalgia syndrome
H B Marchman1, C B Gleason, J C Shaw
1Division of Physical Medicine and Rehabilitation, Frazier Rehabilitation Center, University of Louisville, School of Medicine, KY.
Abstract:
L-tryptophan is an essential amino acid taken as an over-the-counter nutritional supplement for a variety of conditions including chronic pain, insomnia, and depression. In October 1989 several patients were reported having eosinophilia-myalgia syndrome (EMS) who had taken L-tryptophan in large doses. Little is known about the long-term outcomes of EMS. A patient with EMS who developed contractures of the upper extremities because of severe myalgias is discussed. Early aggressive rehabilitative intervention may prevent contractures in patients with EMS.
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