Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Morphological changes in experimental duodenogastric reflux].

D Radev, N Strashimirova, M Vasileva

    Arkhiv Patologii
    |January 1, 1991
    PubMed
    Summary

    Creating a model of duodenal-gastric reflux in dogs revealed significant stomach changes. Importantly, these changes were completely reversible after reflux elimination, suggesting a new term: reflux gastropathy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Extension of the soil monitoring network via tea bag initiatives: A 3000 km latitudinal gradient in European Russia.

    The Science of the total environment·2024
    Same author

    PRIMARY RETROPERITONEAL EXTRA-ORGAN TUMORS (PRET) - SURGICAL TACTICS.

    Khirurgiia·2015
    Same author

    EVOLUTION OF THE IEC AND EN STANDARDS FOR INDIVIDUAL MONITORING OF IONISING RADIATION.

    Radiation protection dosimetry·2015
    Same author

    Clinical and prognostic significance of pathological and inflammatory markers in the surgical treatment of locally advanced colorectal cancer.

    OncoTargets and therapy·2015
    Same author

    Protective effect of spin-labeled 1-ethyl-1-nitrosourea against oxidative stress in liver induced by antitumor drugs and radiation.

    BioMed research international·2013
    Same author

    Video-assisted thyroid resections in the treatment of papillary thyroid carcinoma.

    Khirurgiia·2013

    Area of Science:

    • Gastroenterology
    • Surgical Pathology
    • Veterinary Medicine

    Background:

    • Alkaline reflux-gastritis is a clinical condition.
    • The pathological mechanisms and reversibility are not fully understood.

    Purpose of the Study:

    • To develop a canine model of total duodenal-gastric reflux.
    • To investigate the morphological and bacteriological changes in the stomach.
    • To assess the reversibility of these changes after reflux elimination.

    Main Methods:

    • A total duodenal-gastric reflux model was created in 20 dogs.
    • Histological examination of stomach tissue was performed at 3.5 months and 1 year post-operation.
    • Bacteriological analysis and pH measurements were conducted.
    • A subset of dogs underwent reoperation to eliminate reflux, with subsequent observation.

    Related Experiment Videos

    Main Results:

    • Histological changes included metachromasia, increased mucus, epithelial proliferation, and inflammation.
    • Bacteriological studies revealed increased bacterial population and elevated stomach pH.
    • Reoperation to eliminate reflux led to complete reversibility of all observed morphological changes within 6 months.

    Conclusions:

    • The study established a reproducible canine model of duodenal-gastric reflux.
    • The findings demonstrate that the observed gastric changes are reversible upon elimination of reflux.
    • The authors propose 'reflux gastropathy' as a more accurate term than 'alkaline reflux-gastritis'.