Use of disulfide "staples" to stabilize beta-sheet quaternary structure
Omid Khakshoor1, James S Nowick
1Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
Abstract:
This Letter reports the use of disulfide linkages to stabilize a beta-sheet dimer with a well-defined structure in aqueous and dimethyl sulfoxide solutions. In this dimer, two cyclic beta-sheet peptides are connected by disulfide linkages at the non-hydrogen-bonded rings. The cyclic beta-sheet "domains" interact through hydrogen bonding to form a four-stranded beta-sheet structure. This interaction results in enhanced folding of the cyclic beta-sheet peptides.
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