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Risk factors for fatality in patients with Crimean-Congo haemorrhagic fever

Nuriye Tasdelen Fisgin1, Esra Tanyel, Levent Doganci

  • 1Ondokuz Mayis Universitesi, Tip Fakültesi, Enfeksiyon Hastaliklari AD, Kurupelit, 55139, Samsun, Turkey.

Tropical Doctor
|June 19, 2009
PubMed

Insights

Crimean-Congo haemorrhagic fever (CCHF) is a deadly viral illness. Key indicators of poor prognosis include advanced age, low platelet counts, elevated liver enzymes, and prolonged clotting times.

Area of Science:

  • Virology
  • Infectious Diseases
  • Epidemiology

Background:

  • Crimean-Congo haemorrhagic fever (CCHF) is a severe, potentially fatal viral disease.
  • Understanding prognostic factors is crucial for managing CCHF patients.

Purpose of the Study:

  • To identify prognostic factors influencing survival in CCHF patients.
  • To determine risk factors associated with fatality in CCHF cases.

Main Methods:

  • Retrospective study of CCHF patients (2004-2007) at a tertiary referral center.
  • Patients categorized into survival (n=44) and fatality (n=6) groups.
  • Analysis of clinical data, laboratory results (platelet count, liver enzymes, LDH, CPK, PT, aPTT), and age.

Main Results:

  • Fatal cases showed significantly lower platelet counts (11,000/mm³ vs. 49,500/mm³).
  • Elevated AST, ALT, CPK, and LDH levels were observed in the fatal group.
  • Prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT) were noted in fatal cases.
  • Advanced age and late admission were also associated with increased fatality.

Conclusions:

  • Advanced age, late admission, low platelet count, elevated liver enzymes (AST, ALT), increased CPK and LDH, and prolonged PT/aPTT are indicators of poor prognosis in CCHF.
  • These factors can aid in early risk stratification and management of CCHF patients.
  • Further research may refine prognostic models for CCHF.

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