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Related Experiment Video

Updated: Jun 22, 2026

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

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Published on: November 26, 2019

Tooth loss and cognitive impairment.

Hans Joergen Grabe¹, Christian Schwahn, Henry Völzke

¹Department of Psychiatry and Psychotherapy, HANSE-Klinikum Stralsund, Ernst-Moritz-Arndt-University of Greifswald, Stralsund, Germany. grabeh@uni-greifswald.de

Journal of Clinical Periodontology

|June 23, 2009

Summary

Tooth loss, often caused by periodontitis, is linked to cognitive impairment in elderly women. This study highlights a potential connection between oral health and brain health in older adults.

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Gerontology
Oral Health
Neuroscience

Background:

Chronic subclinical inflammation is a risk factor for cognitive impairment.
Periodontitis, a common inflammatory condition, is associated with tooth loss.

Purpose of the Study:

To investigate the association between periodontitis, tooth loss, and cognitive impairment in the elderly.
To test the hypothesis that tooth loss as a proxy for chronic periodontitis increases cognitive impairment risk.

Main Methods:

A population-based study of 1336 subjects aged 60-79 years (Study of Health in Pomerania).
Cognitive function assessed using the Mini-Mental Status Examination (MMSE).
Tobit regression analyses were employed, adjusting for potential confounders.

Main Results:

Decreased tooth count correlated with lower MMSE scores in both females and males (age-adjusted).
Tooth loss was significantly associated with cognitive impairment in females (fully adjusted models).
No significant association was found between tooth loss and cognitive impairment in males (fully adjusted models).

Conclusions:

A significant association exists between tooth loss and cognitive impairment in elderly females, independent of confounders.
Periodontitis, a frequent cause of tooth extraction, may underlie this observed association.
Findings suggest a link between oral health status and cognitive function in older women.